Aging
Our work in Aging
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Blood Pressure Medication and Dementia Prevention: The Promising Link
SC Schaeffer Center researchers have turned to real-world data to probe the relationship between antihypertensive use and dementia risk in the U.S. population and among minoritized populations who are at the highest risk of dementia.
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Does Adding MRI and CSF-Based Biomarkers Improve Cognitive Status Classification Based on Cognitive Performance Questionnaires?
MRI and CSF biomarkers, while important for understanding dementia pathology in clinical research, were not found to substantially improve cognitive status classification based on cognitive status performance.
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Aging on the Job? The Association Between Occupational Characteristics and Accelerated Biological Aging
Adverse occupational characteristics held at midlife, particularly service work, low job control, heavy lifting, and long work hours, are associated with accelerated biological aging.
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Potentially Inappropriate Medication Use in Community-Dwelling Older Adults Living with Dementia
The Beers Criteria identifies potentially inappropriate medications (PIMs) that should be avoided in older adults living with dementia.
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Cross-National Differences in Wealth Inequality in Health Services and Caregiving Used Near the End of Life
Wealth inequality in end of life care exists across countries and reflects differences in the organization, financing, and delivery of care in different countries.
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Age Differences in Social Decision-Making Preferences and Perceived Ability
Older age was associated with being less likely to prefer social decision-making.
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Epigenetic-Based Age Acceleration in a Representative Sample of Older Americans: Associations with Aging-Related Morbidity and Mortality
While the usefulness of DNAm-based age acceleration as a predictor of later life health outcomes is quite clear, other factors such as demographics, SES, mental health, and health behaviors remain equally, if not more robust, predictors of later life outcomes.
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Effectiveness and Cost-Effectiveness of Palliative Care in Natural Experiments: a Systematic Review
Schaeffer researchers reviewed studies that employed ‘natural experiments’ to evaluate palliative care and considered implications for expanding use of these methods.
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COVID-19 Hospitalization and Mortality in Community-Dwelling Racially and Ethnically Diverse Persons Living with Dementia
Community-dwelling persons living with dementia (PLWD) are vulnerable to COVID-19 infection, severity, and mortality due to the high prevalence of comorbidities, reliance on caregivers, and potential inability to employ risk reduction measures, among other factors.
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2023 Clinical Trial Recruitment Lab (CTRL) Request for Pilot Project Proposals
CTRL is seeking proposals for pilot projects that test strategies and solutions designed to address barriers to recruitment for Alzheimer’s disease clinical trials.